Clinical Focus
Pulmonary Medicine
Professional Education
BS: Medicine, Memorial University of Newfoundland, St. John’s Newfoundland, Canada
Medical Degree: Memorial University of Newfoundland, St. John’s Newfoundland, Canada
Residency: Internal Medicine, Toronto General Hospital, Toronto, Ontario, Canada
Residency: Internal Medicine, University Hospital, University of Alberta, Edmonton, Alberta, Canada
Fellowship: Pulmonary Medicine, Toronto General Hospital, Toronto, Ontario, Canada
Fellowship: Clinical Pulmonary Transplant Research, Toronto Lung Transplant Group, University of Toronto, Ontario, Canada
Fellowship: Pulmonary Medicine, McGill University, Montreal, Canada
Board Certification
Internal Medicine
Pulmonary Medicine
Critical Care Medicine
Clinical and Research Interests
- Active researcher on the disease states of idiopathic pulmonary fibrosis, pulmonary hypertension, pulmonary arterial hypertension, chronic thromboembolic pulmonary hypertension, and port-pulmonary hypertension
- Reviewer for Circulation, Journal of Heart and Lung Transplantation, Transplantation, and Chest journals
- Member of International Society of Heart and Lung Transplantation (ISHLT), American Society of Transplantation, Society of Critical Care Medicine, and American Thoracic Society
- Chairman of Working Group on Predictors of Outcome Post Transplant in Pulmonary Hypertension for ISHLT
- Steering committee member of AIRES, AMBITION, IKARIA, REVEAL Registry, and PROSPECT Registry multi-center international research groups
- Fellow of the Royal College of Physicians and Surgeons of Canada, Medicine, American College of Chest Physicians
Recent Publications
1: Hoeper MM, Barst RJ, Bourge RC, Feldman J, Frost AE, Galié N, Gómez-Sánchez
MA, Grimminger F, Grünig E, Hassoun PM, Morrell NW, Peacock AJ, Satoh T,
Simonneau G, Tapson VF, Torres F, Lawrence D, Quinn DA, Ghofrani HA. Imatinib
Mesylate as Add-On Therapy for Pulmonary Arterial Hypertension: Results of the
Randomized IMPRES Study. Circulation. 2013 Feb 12. [Epub ahead of print] PubMed
PMID: 23403476.
2: Benza RL, Gomberg-Maitland M, Frost AE, Frantz RP, Humbert M, McGoon MD.
Development of prognostic tools in pulmonary arterial hypertension: lessons from
modern day registries. Thromb Haemost. 2012 Dec;108(6):1049-60. doi:
10.1160/TH11-11-0821. Epub 2012 Sep 5. PubMed PMID: 22955290.
3: Frost AE, Farber HW, Barst RJ, Miller DP, Elliott CG, McGoon MD. Demographics
and outcomes of patients diagnosed with pulmonary hypertension with pulmonary
capillary wedge pressures 16 to 18 mm Hg: insights from the REVEAL Registry.
Chest. 2013 Jan;143(1):185-95. PubMed PMID: 22661451.
4: Tapson VF, Torres F, Kermeen F, Keogh AM, Allen RP, Frantz RP, Badesch DB,
Frost AE, Shapiro SM, Laliberte K, Sigman J, Arneson C, Galiè N. Oral
treprostinil for the treatment of pulmonary arterial hypertension in patients on
background endothelin receptor antagonist and/or phosphodiesterase type 5
inhibitor therapy (the FREEDOM-C study): a randomized controlled trial. Chest.
2012 Dec;142(6):1383-90. doi: 10.1378/chest.11-2212. PubMed PMID: 22628490.