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Macitentan in PH Due to LV Dysfunction: MELODY-1
PH is a common coincidence with heart failure. Recent guidelines identified 2 types of Group 2 PH, isolated post-capillary PH and combined pre and post capillary PH (CpcPH), which in heart failure patients are associated with elevated endothelin-1 levels. The effects of macitentan on fluid retention are particularly important and may serve to alter physicians’ perceptions for use of this medication in Group 2 patients. Dr. Lewis Rubin discusses the design and results of the MELODY-1 trial, macitentan in PH due to LV dysfunction.
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